Zoledronic acid belongs to the family of medications known as bisphosphonates.
This medication is used to treat high blood calcium levels (hypercalcemia) that may occur with cancer. Zoledronic acid is also used with cancer chemotherapy to treat bone problems that may occur with multiple myeloma and other types of cancer(such as breast, lung) that have spread to the bones. It lowers high blood calcium levels by reducing the amount of calcium released from your bones into your blood. It also works by slowing the breakdown of your bones by cancer.
In some cancers there can be an excessive breakdown of bone. As this happens, calcium is lost from the bone and seeps into the blood, leading to higher than normal levels of calcium in the blood. This is called hypercalcaemia. Zoledronic acid binds to bone and reduces the rate at which it is broken down. This helps to strengthen bones and prevents the loss of calcium. This in turn reduces the high levels of calcium in the blood.
Aclasta is also used to treats Paget’s disease and osteoporosis in postmenopausal women.
Aclasta is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion, and can take at least 15 minutes to complete.
Aclasta is sometimes given only once per year. Follow your doctor’s instructions.
Drink at least 2 glasses of water within a few hours before your injection to keep from getting dehydrated.
Your doctor may want you to take a calcium and/or vitamin D supplement while you are being treated with Aclasta. Carefully follow your doctor’s instructions about the type and strength of calcium to take.
To be sure Aclasta is helping your condition and not causing harmful side effects, your blood will need to be tested on a regular basis. Your kidney function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.
Dizziness, headache, or flu-like symptoms (such as fever, chills, muscle/joint aches) may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.
Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: increased or severe bone/joint/muscle pain, new or unusual hip/thigh/groin pain, jaw pain,eye/vision problems, numbness/tingling, muscle spasms, irregular heartbeat.
Get medical help right away if you have any serious side effects, including: signs of kidney problems (such as change in the amount of urine), seizures.
Before using zoledronic acid, tell your doctor or pharmacist if you
• are allergic to it; or to other bisphosphonates (such as alendronate, risedronate); or if you have any other allergies.
• This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
• tell your doctor or pharmacist your medical history, especially of: kidney problems, loss of too much body water (dehydration), aspirin-sensitive asthma.
• Some people using zoledronic acid may have serious jawbone problems. Your doctor should check your mouth before you start this medication.
• Tell your dentist that you are using this medication before you have any dental work done.
• Before having any surgery (especially dental procedures), tell your doctor and dentist about this medication and all other products you use (including prescription drugs, nonprescription drugs, and herbal products).
• This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely.